Download Age-related macular degeneration : a comprehensive textbook by D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. PDF

By D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD

A well known crew of retina surgeons offers promising new advancements in age-related macular degeneration, with emphasis at the most vital advances some time past 5 years. content material addresses all facets of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in age-related macular degeneration; prevention measures and therapy; therapy; and destiny instructions. Abundantly illustrated and beautifully prepared, this ebook serves as a good reference and textbook.

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Hum Mol Genet. 1995; 4:1,4031,409. 47. Wang F, Rendahl KG, Manning WC, et al. AAV-mediated expression of vascular endothelial growth factor induces choroidal neovascularization in rat. Invest Ophthalmol Vis Sci. 2003;44:781-790. 77. Van der Schaft TL, de Bruijn WC, Mooy CM, et al. Basal laminar deposit in the aging peripheral human retina. Graefes Arch Clin Exp Ophthalmol. 1993;231:470-475. 48. Soubrane G, Cohen SY, Delayre T, et al. Basic fibroblast growth factor experimentally induced choroidal angiogenesis in the minipig.

Documenta Ophthalmologica. 1990;74:163-169. 52. Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983;219:983-985. 82. Penn JS, Tolman BL, Lower LA. Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Invest Ophthalmol Vis Sci. 1993;34:576585. 53. Murata T, Nakagawa K, Khalil A, et al. The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas.

In between the plasma membrane and the basement membrane an accumulation of material, including widespaced collagen occurs. This material is called basal laminar deposit. External to the basement membrane a material called basal linear deposit accumulates. This material has a high lipid content with membranous debris. Mounds of this material are visible as soft drusen. With age there is also an increased amount of lipofuscin in the RPE cell as well as thickening, calcification, and potential fracture (not shown) of Bruch's membrane.

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