By Sally Nicholls
A perilous contagion races via England...
Isabel and her family members have nowhere to run from a affliction that has killed half Europe. while the area she understands and loves ends perpetually, her in simple terms weapon is courage.
The Black dying of 1349 was once the deadliest plague in human historical past. All Fall Down is a strong and encouraging tale of survival within the face of actual lifestyles horror.
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Guyatt G, Keller J, Jaeschke R, Rosenbloom D, Adachi J, Newhouse M. The n-of-1 randomized controlled trial: clinical usefulness: our three-year experience. Ann Intern Med. 1990;112(4):293-299. 6. Larson E, Ellsworth A, Oas J. Randomized clinical trials in single patients during a 2-year period. JAMA. 1993;270(22):2708-2712. 7. Mahon J, Laupacis A, Donner A, Wood T. Randomised study of n of 1 trials versus standard practice. BMJ. 1996;312(7038):1069-1074. 8. Guyatt G, DiCenso A, Farewell V, Willan A, Griffith L.
References 1. Yusuf S. Intensive insulin-glucose infusion regimens with long-term or standard glucose control did not differ for reducing mortality in type 2 diabetes mellitus and MI. ACP J Club. 2005;143(2):43. 2. Kenealy TAB. Review: mixed signals from trials concerning pharmacological prevention of type 2 diabetes mellitus. ACP J Club. 2005;143(2):44. 31 This page intentionally left blank 4 FINDING THE EVIDENCE Ann McKibbon, Peter Wyer, Roman Jaeschke, and Dereck Hunt IN THIS CHAPTER: Introduction Four Categories of Information Sources and How Clinicians Use Them Searching the Medical Literature Is Sometimes Futile Four Criteria for Choosing Information Resources Soundness of Evidence-Based Approach Comprehensiveness and Specificity Ease of Use Availability Information Sources That Do Well on at Least Some Criteria Textbook-Like Resources (Systems) Preappraised Resources (Synopses) Systematic Reviews and Guidelines (Summaries) Original/Primary Studies (Studies) Alerting or Updating Services Other Resources Format 33 Copyright © 2008 by the American Medical Association.
1999;318(7175):48-50. 16. Haynes R. Of studies, syntheses, synopses, and systems: the “4S” evolution of services for finding current best evidence. ACP J Club. 2001;134(2):A11-A13. 17. Muir Gray F, Haynes R, Sackett D, Cook D, Guyatt G. Transferring evidence from research into practice, III: developing evidence-based clinical policy. ACP J Club. 1997;126(2):A14-A16. 15 This page intentionally left blank 3 WHAT IS THE QUESTION? Gordon Guyatt, Maureen O. Meade, Scott Richardson, and Roman Jaeschke IN THIS CHAPTER: Three Ways to Use the Medical Literature Browsing Problem Solving Background and Foreground Questions Clarifying Your Question The Structure: Patients, Exposure, Outcome Five Types of Clinical Questions Finding a Suitably Designed Study for Your Question Type Three Examples of Question Clarification Example 1: Diabetes and Target Blood Pressure Example 2: Transient Loss of Consciousness Example 3: Squamous Cell Carcinoma Defining the Question: Conclusion 17 Copyright © 2008 by the American Medical Association.