Download Alzheimer's disease and related disorders annual. / 2004 by Philip Scheltens MD PhD, Serge Gauthier, Philip Scheltens, PDF

By Philip Scheltens MD PhD, Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings

content material: Innervation of Senile Plaques: A hyperlink among Amyloid and Neurofibrillary Pathology? B. Delatour, V. Blanchard, L. Pradier, and C. Duyckaerts Vascular elements and Alzheimer's disorder, I. Skoog, D. Gustafson, and M. Sjogren The position of White topic Lesions in Dementia, L. Pantoni Subclassification of gentle Cognitive Impairment in learn and medical perform, S. Gauthier and J. Touchon Neuropsychiatric features of light Cognitive Impairment, T.J. Hung and J.L. Cummings Cognitive Rehabilitation in gentle Cognitive Impairment and Prodromal Alzheimer's illness, M. van der Linden, A.-C. Juillerat, and X. Delbeuck scientific Trial layout within the Age of Dementia remedies: demanding situations and possibilities, E. Mohr, C.L. Barclay, R. Anderson, and J. consistent Ethics of analysis in Dementia, J. Karlawish Memantine: A Glutamate Antagonist for remedy of Alzheimer's affliction, R. Smith Doody, B. Winbald, and V. Jelic administration of Comorbidity in Alzheimer's ailment, R. Jones dietary Prevention in Alzheimer's ailment, O. Guerin and B. Vellas Index

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Hitherto, two clinical prospective trials have been performed. In a doubleblind, placebo-controlled randomized trial, 44 patients with AD were studied for the possible effect of simvastatin treatment. Both clinical and biochemical measures were investigated. 126 In a second study, 19 patients with AD were treated in an open trial with 20 mg simvastatin for 12 weeks. 001), but the CSF levels of tau, phospho-tau, and Aβ42 and the plasma levels of Ap were unchanged. 05). 127 However, since both these studies followed patients who already had AD, and for a rather short time period, future studies must follow AD patients for a longer time, and initiate treatment at an early stage or even before the manifestations of the disease.

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Jick H, Zornberg GL, Jick SS et al. Statins and the risk of dementia. Lancet 2000; 356: 1627–1631. 124. Wolozin B, Kellman W, Ruosseau P et al. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000; 57:1439–1443. 125. Rockwood K, Kirkland S, Hogan DB et al. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Arch Neurol 2002; 59:223–227. 126. Simons M, Schwarzler F, Lutjohann D et al.

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